PUBLICATIONS
(Click on the title for links to the papers)
A complete list of publications can be found on PubMed and Google Scholar.
Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer.
Klomp JE, Diehl JN, Klomp JA, Edwards AC, Yang R, Morales AJ, Taylor KE, Drizyte-Miller K, Bryant KL, Schaefer A, Johnson JL, Huntsman EM, Yaron TM, Pierobon M, Baldelli E, Prevatte AW, Barker NK, Herring LE, Petricoin EF 3rd, Graves LM, Cantley LC, Cox AD, Der CJ, Stalnecker CA. Science 2024, doi: 10.1126/science.adk0850.
Commentary in NIH Director's Blog
Recurrent RhoGAP gene fusion CLDN18-ARHGAP26 promotes RHOA activation and focal adhesion kinase and YAP-TEAD signalling in diffuse gastric cancer.
Zhang F, Sahu V, Peng K, Wang Y, Li T, Bala P, Aitymbayev D, Sahgal P, Schaefer A, Der CJ, Ryeom S, Yoon S, Sethi N, Bass AJ, Zhang H. Gut 2024, doi: 10.1136/gutjnl-2023-329686.
RHOA-L57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling.
Schaefer A*, Hodge RG, Zhang H, Hobbs GA, Dilly J, Huynh MV, Goodwin CM, Zhang F, Diehl JN, Pierobon M, Baldelli E, Javaid S, Guthrie K, Rashid NU, Petricoin EF, Cox AD, Hahn WC, Aguirre AJ, Bass AJ, Der CJ*. Science Signaling 2023, doi: 10.1126/scisignal.adg5289. * co-corresponding authors.
Commentary in Science Signaling
Klomp JE, Diehl JN, Klomp JA, Edwards AC, Yang R, Morales AJ, Taylor KE, Drizyte-Miller K, Bryant KL, Schaefer A, Johnson JL, Huntsman EM, Yaron TM, Pierobon M, Baldelli E, Prevatte AW, Barker NK, Herring LE, Petricoin EF 3rd, Graves LM, Cantley LC, Cox AD, Der CJ, Stalnecker CA. Science 2024, doi: 10.1126/science.adk0850.
Commentary in NIH Director's Blog
Recurrent RhoGAP gene fusion CLDN18-ARHGAP26 promotes RHOA activation and focal adhesion kinase and YAP-TEAD signalling in diffuse gastric cancer.
Zhang F, Sahu V, Peng K, Wang Y, Li T, Bala P, Aitymbayev D, Sahgal P, Schaefer A, Der CJ, Ryeom S, Yoon S, Sethi N, Bass AJ, Zhang H. Gut 2024, doi: 10.1136/gutjnl-2023-329686.
RHOA-L57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling.
Schaefer A*, Hodge RG, Zhang H, Hobbs GA, Dilly J, Huynh MV, Goodwin CM, Zhang F, Diehl JN, Pierobon M, Baldelli E, Javaid S, Guthrie K, Rashid NU, Petricoin EF, Cox AD, Hahn WC, Aguirre AJ, Bass AJ, Der CJ*. Science Signaling 2023, doi: 10.1126/scisignal.adg5289. * co-corresponding authors.
Commentary in Science Signaling
Functional and biological heterogeneity of KRASQ61 mutations.
Huynh MV, Hobbs GA, Schaefer A, Pierobon M, Carey LM, Diehl JN, DeLiberty JM, Thurman RD, Cooke AR, Goodwin CM, Cook JH, Lin L, Waters AM, Rashid NU, Petricoin EF 3rd, Campbell SL, Haigis KM, Simeone DM, Lyssiotis CA, Cox AD, Der CJ. Science Signaling 2022, doi: 10.1126/scisignal.abn2694. Commentary in Science Signaling |
RHOA takes the RHOad less traveled to cancer.
Schaefer A, Der CJ. Trends in Cancer 2022, doi: 10.1016/j.trecan.2022.04.005.
Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma.
Javaid S, Schaefer A, Goodwin CM, Nguyen VV, Massey FL, Pierobon M, Gambrell-Sanders D, Waters AM, Lambert KN, Diehl JN, Hobbs GA, Wood KC, Petricoin EF, Der CJ, Cox AD. Molecular Cancer Therapeutics 2022, doi: 10.1158/1535-7163.MCT-21-0142.
Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth.
Cook DR, Kang M, Martin TD, Galanko JA, Loeza GH, Trembath DG, Justilien V, Pickering KA, Vincent DF, Jarosch A, Jurmeister P, Waters AM, Hibshman PS, Campbell AD, Ford CA, Keku TO, Yeh JJ, Lee MS, Cox AD, Fields AP, Sandler RS, Sansom OJ, Sers C, Schaefer A*, Der CJ*. Cancer Research 2022, doi: 10.1158/0008-5472.CAN-20-4218. * co-corresponding authors.
Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition.
Waters AM, Khatib TO, Papke B, Goodwin CM, Hobbs GA, Diehl JN, Yang R, Edwards AC, Walsh KH, Sulahian R, McFarland JM, Kapner KS, Gilbert TSK, Stalnecker CA, Javaid S, Barkovskaya A, Grover KR, Hibshman PS, Blake DR, Schaefer A, Nowak KM, Klomp JE, Hayes TK, Kassner M, Tang N, Tanaseichuk O, Chen K, Zhou Y, Kalkat M, Herring LE, Graves LM, Penn LZ, Yin HH, Aguirre AJ, Hahn WC, Cox AD, Der CJ. Cell Reports 2021, doi: 10.1016/j.celrep.2021.109291.
RAS and RHO family GTPase mutations in cancer: twin sons of different mothers?
Hodge RG^, Schaefer A ^,*, Howard SV, Der CJ*. Critical Reviews in Biochemistry and Molecular Biology 2020, doi: 10.1080/10409238.2020.1810622. ^ co-first authors, * co-corresponding authors.
Schaefer A, Der CJ. Trends in Cancer 2022, doi: 10.1016/j.trecan.2022.04.005.
Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma.
Javaid S, Schaefer A, Goodwin CM, Nguyen VV, Massey FL, Pierobon M, Gambrell-Sanders D, Waters AM, Lambert KN, Diehl JN, Hobbs GA, Wood KC, Petricoin EF, Der CJ, Cox AD. Molecular Cancer Therapeutics 2022, doi: 10.1158/1535-7163.MCT-21-0142.
Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth.
Cook DR, Kang M, Martin TD, Galanko JA, Loeza GH, Trembath DG, Justilien V, Pickering KA, Vincent DF, Jarosch A, Jurmeister P, Waters AM, Hibshman PS, Campbell AD, Ford CA, Keku TO, Yeh JJ, Lee MS, Cox AD, Fields AP, Sandler RS, Sansom OJ, Sers C, Schaefer A*, Der CJ*. Cancer Research 2022, doi: 10.1158/0008-5472.CAN-20-4218. * co-corresponding authors.
Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition.
Waters AM, Khatib TO, Papke B, Goodwin CM, Hobbs GA, Diehl JN, Yang R, Edwards AC, Walsh KH, Sulahian R, McFarland JM, Kapner KS, Gilbert TSK, Stalnecker CA, Javaid S, Barkovskaya A, Grover KR, Hibshman PS, Blake DR, Schaefer A, Nowak KM, Klomp JE, Hayes TK, Kassner M, Tang N, Tanaseichuk O, Chen K, Zhou Y, Kalkat M, Herring LE, Graves LM, Penn LZ, Yin HH, Aguirre AJ, Hahn WC, Cox AD, Der CJ. Cell Reports 2021, doi: 10.1016/j.celrep.2021.109291.
RAS and RHO family GTPase mutations in cancer: twin sons of different mothers?
Hodge RG^, Schaefer A ^,*, Howard SV, Der CJ*. Critical Reviews in Biochemistry and Molecular Biology 2020, doi: 10.1080/10409238.2020.1810622. ^ co-first authors, * co-corresponding authors.

Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer.
Zhang H^, Schaefer A^, Wang Y, Hodge RG, Blake DR, Diehl JN, Papageorge AG, Stachler MD, Liao J, Zhou J, Wu Z, Akarca FG, de Klerk LK, Derks S, Pierobon M, Hoadley KA, Wang TC, Church G, Wong KK, Petricoin EF, Cox AD, Lowy DR, Der CJ, Bass AJ. Cancer Discovery 2020, doi: 10.1158/2159-8290.CD-19-0811. ^ co-first authors.
Commentary in Cancer Discovery.
Zhang H^, Schaefer A^, Wang Y, Hodge RG, Blake DR, Diehl JN, Papageorge AG, Stachler MD, Liao J, Zhou J, Wu Z, Akarca FG, de Klerk LK, Derks S, Pierobon M, Hoadley KA, Wang TC, Church G, Wong KK, Petricoin EF, Cox AD, Lowy DR, Der CJ, Bass AJ. Cancer Discovery 2020, doi: 10.1158/2159-8290.CD-19-0811. ^ co-first authors.
Commentary in Cancer Discovery.
Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers.
Ozkan-Dagliyan I, Diehl JN, George SD, Schaefer A, Papke B, Klotz-Noack K, Waters AM, Goodwin CM, Gautam P, Pierobon M, Peng S, Gilbert TSK, Lin KH, Dagliyan O, Wennerberg K, Petricoin EF 3rd, Tran NL, Bhagwat SV, Tiu RV, Peng SB, Herring LE, Graves LM, Sers C, Wood KC, Cox AD, Der CJ. Cell Reports 2020, doi: 10.1016/j.celrep.2020.107764.
The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2.
Arrington ME, Temple B , Schaefer A , Campbell SL. Journal of Biological Chemistry 2020, doi: 10.1074/jbc.RA120.012915.
Inflammation-Sensitive Myosin-X Functionally Supports Leukocyte Extravasation by Cdc42-Mediated ICAM-1-Rich Endothelial Filopodia Formation.
Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Alphen F, Hordijk P, Stroes ESG, Strömblad S, van Rheenen J, van Buul JD. Journal of Immunology 2018, doi: 10.4049/jimmunol.1700702.
Ozkan-Dagliyan I, Diehl JN, George SD, Schaefer A, Papke B, Klotz-Noack K, Waters AM, Goodwin CM, Gautam P, Pierobon M, Peng S, Gilbert TSK, Lin KH, Dagliyan O, Wennerberg K, Petricoin EF 3rd, Tran NL, Bhagwat SV, Tiu RV, Peng SB, Herring LE, Graves LM, Sers C, Wood KC, Cox AD, Der CJ. Cell Reports 2020, doi: 10.1016/j.celrep.2020.107764.
The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2.
Arrington ME, Temple B , Schaefer A , Campbell SL. Journal of Biological Chemistry 2020, doi: 10.1074/jbc.RA120.012915.
Inflammation-Sensitive Myosin-X Functionally Supports Leukocyte Extravasation by Cdc42-Mediated ICAM-1-Rich Endothelial Filopodia Formation.
Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Alphen F, Hordijk P, Stroes ESG, Strömblad S, van Rheenen J, van Buul JD. Journal of Immunology 2018, doi: 10.4049/jimmunol.1700702.
Endothelial CD2AP Binds the Receptor ICAM-1 To Control Mechanosignaling, Leukocyte Adhesion, and the Route of Leukocyte Diapedesis In Vitro.
Schaefer A*, van Duijn TJ, Majolee J, Burridge K, Hordijk PL. Journal of Immunology 2017, doi: 10.4049/jimmunol.1601987. * corresponding author. |
A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1.
Timmerman I, Heemskerk N, Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Unen J, Goedhart J, Gadella TW Jr, Yin T, Wu Y, Huveneers S, van Buul JD. Journal of Cell Science 2015, doi: 10.1242/jcs.168674.
Cell-stiffness-induced mechanosignaling - a key driver of leukocyte transendothelial migration.
Schaefer A*, Hordijk PL. Journal of Cell Science 2015, doi: 10.1242/jcs.163055. * corresponding author.
Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration.
Schaefer A*, Te Riet J, Ritz K, Hoogenboezem M, Anthony EC, Mul FP, de Vries CJ, Daemen MJ, Figdor CG, van Buul JD, Hordijk PL*. Journal of Cell Science 2014, doi: 10.1242/jcs.154708. * co-corresponding authors.
Highlighted in Development.
Toward understanding RhoGTPase specificity: structure, function and local activation.
Schaefer A, Reinhard NR, Hordijk PL. Small GTPases, 2014, doi: 10.4161/21541248.2014.968004.
The human minor histocompatibility antigen 1 is a RhoGAP.
de Kreuk BJ, Schaefer A, Anthony EC, Tol S, Fernandez-Borja M, Geerts D, Pool J, Hambach L, Goulmy E, Hordijk PL. PLoS One 2013, doi: 10.1371/journal.pone.0073962.
Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration.
Schaefer A, Nethe M, Hordijk PL. Biochemical Journal 2012, doi: 10.1042/BJ20111815.
Dimeric plant RhoGAPs are regulated by its CRIB effector motif to stimulate a sequential GTP hydrolysis.
Schaefer A, Miertzschke M, Berken A, Wittinghofer A. Journal of Molecular Biology 2011, doi: 10.1016/j.jmb.2011.06.033.
Rho proteins of plants - functional cycle and regulation of cytoskeletal dynamics.
Mucha E, Fricke I, Schaefer A, Wittinghofer A, Berken A. European Journal of Cell Biology 2011, doi: 10.1016/j.ejcb.2010.11.009.
Timmerman I, Heemskerk N, Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Unen J, Goedhart J, Gadella TW Jr, Yin T, Wu Y, Huveneers S, van Buul JD. Journal of Cell Science 2015, doi: 10.1242/jcs.168674.
Cell-stiffness-induced mechanosignaling - a key driver of leukocyte transendothelial migration.
Schaefer A*, Hordijk PL. Journal of Cell Science 2015, doi: 10.1242/jcs.163055. * corresponding author.
Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration.
Schaefer A*, Te Riet J, Ritz K, Hoogenboezem M, Anthony EC, Mul FP, de Vries CJ, Daemen MJ, Figdor CG, van Buul JD, Hordijk PL*. Journal of Cell Science 2014, doi: 10.1242/jcs.154708. * co-corresponding authors.
Highlighted in Development.
Toward understanding RhoGTPase specificity: structure, function and local activation.
Schaefer A, Reinhard NR, Hordijk PL. Small GTPases, 2014, doi: 10.4161/21541248.2014.968004.
The human minor histocompatibility antigen 1 is a RhoGAP.
de Kreuk BJ, Schaefer A, Anthony EC, Tol S, Fernandez-Borja M, Geerts D, Pool J, Hambach L, Goulmy E, Hordijk PL. PLoS One 2013, doi: 10.1371/journal.pone.0073962.
Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration.
Schaefer A, Nethe M, Hordijk PL. Biochemical Journal 2012, doi: 10.1042/BJ20111815.
Dimeric plant RhoGAPs are regulated by its CRIB effector motif to stimulate a sequential GTP hydrolysis.
Schaefer A, Miertzschke M, Berken A, Wittinghofer A. Journal of Molecular Biology 2011, doi: 10.1016/j.jmb.2011.06.033.
Rho proteins of plants - functional cycle and regulation of cytoskeletal dynamics.
Mucha E, Fricke I, Schaefer A, Wittinghofer A, Berken A. European Journal of Cell Biology 2011, doi: 10.1016/j.ejcb.2010.11.009.
The unique plant RhoGAPs are dimeric and contain a CRIB motif required for affinity and specificity towards cognate small G proteins.
Schaefer A, Höhner K, Berken A, Wittinghofer A. Biopolymers 2011, doi: 10.1002/bip.21601. |
Copyright: 2024 A. Schaefer. All rights reserved.